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Cyclin-dependent kinase 2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL

BDBM50234990(CHEMBL4062453)

IC50: 370nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Cyclin-dependent kinase 2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL

BDBM50086441(CHEMBL3426225 | US10266537, Compound 3)

IC50: >1.00E+4nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Filter my 10713 hits

Targets 388▿
- Palmitoleoyl-protein carboxylesterase NOTUM 599
- Bromodomain-containing protein 4 472
- Rho-associated protein kinase 2 362
- G-protein coupled receptor 35 342
- 11-beta-hydroxysteroid dehydrogenase 1 330
- Rho-associated protein kinase 1 321
- E3 ubiquitin-protein ligase Mdm2 291
- Epidermal growth factor receptor 285
- Nuclear receptor ROR-gamma 268
- Tyrosine-protein kinase BTK 226
- Type-2 angiotensin II receptor 221
- Hepatocyte growth factor receptor 216
- Poly [ADP-ribose] polymerase 1 149
- Vascular endothelial growth factor receptor 2 146
- Acetylcholinesterase 138
- Rho-associated protein kinase 2 [1-119] 133
- Coagulation factor X 130
- Sphingosine 1-phosphate receptor 1 121
- Cytochrome P450 3A4 119
- Dihydroorotate dehydrogenase (quinone), mitochondrial 118
- Cholinesterase 110
- Programmed cell death 1 ligand/protein 1 105
- Sphingosine 1-phosphate receptor 3 96
- Sentrin-specific protease 1 93
- Urea transporter 1 88
- Platelet-derived growth factor receptor beta 81
- RAC-alpha serine/threonine-protein kinase 81
- Induced myeloid leukemia cell differentiation protein Mcl-1 79
- Cytochrome P450 2C9 72
- Fibroblast growth factor receptor 1 72
- Casein kinase II subunit alpha' 71
- Casein kinase II subunit alpha 71
- Tyrosine-protein phosphatase non-receptor type 1 70
- Bromodomain-containing protein 2 [364-436] 70
- Serine/threonine-protein kinase TNNI3K 68
- Bromodomain-containing protein 2 68
- Oxysterols receptor LXR-beta 68
- Oxysterols receptor LXR-alpha 68
- Cytochrome P450 2D6 68
- Bromodomain-containing protein 3 66
- Beta-secretase 1 66
- Proteasome subunit beta type-5 66
- D-3-phosphoglycerate dehydrogenase 63
- Lysine-specific histone demethylase 1A 62
- Mitogen-activated protein kinase kinase kinase 14 58
- C-X-C chemokine receptor type 2 57
- Sentrin-specific protease 2 57
- Beta-2 adrenergic receptor 55
- Estrogen receptor 53
- Sentrin-specific protease 5 53
- Eukaryotic elongation factor 2 kinase 50
- Similar to alpha-tubulin isoform 1 50
- Vascular endothelial growth factor receptor 1 49
- 5-hydroxytryptamine receptor 1A 48
- Polycomb protein EED 46
- Mitogen-activated protein kinase kinase kinase 5 46
- Serine/threonine-protein kinase B-raf 46
- Histone deacetylase 1 46
- Platelet-derived growth factor receptor alpha 46
- Serine/threonine-protein kinase PLK1 45
- Translocator protein 45
- Polyphenol oxidase 2 45
- Caspase-3 45
- Tyrosine-protein kinase JAK2 44
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 43
- Tyrosine-protein kinase Tec 42
- ATP-dependent translocase ABCB1 42
- Type-1 angiotensin II receptor 40
- Bifunctional epoxide hydrolase 2 40
- Caspase-7 38
- Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha 38
- 11-beta-hydroxysteroid dehydrogenase type 2 37
- Neurogenic locus notch homolog protein 3 37
- Neurogenic locus notch homolog protein 1 37
- Apoptosis regulator Bcl-2 37
- Beta-1 adrenergic receptor 35
- ...
Publications 50▿
- US Patent US11390609 (2022) 592
- US Patent US11634391 (2023) 255
- Bioorg Med Chem Lett 22: 4979-85 (2012) 223
- US Patent US9675697 (2017) 203
- US Patent US9079913 (2015) 185
- J Med Chem 60: 3887-3901 (2017) 185
- US Patent US11453690 (2022) 171
- Eur J Med Chem 204: (2020) 163
- J Med Chem 63: 15541-15563 (2020) 157
- US Patent US8940736 (2015) 142
- J Med Chem 58: 4927-39 (2015) 141
- Bioorg Med Chem 25: 3649-3657 (2017) 140
- Eur J Med Chem 194: (2020) 138
- J Med Chem 64: 2634-2647 (2021) 133
- J Med Chem 54: 6050-62 (2011) 130
- US Patent US10329282 (2019) 123
- Eur J Med Chem 96: 369-80 (2015) 121
- Bioorg Med Chem Lett 20: 6725-9 (2010) 110
- J Med Chem 62: 7264-7288 (2019) 108
- Eur J Med Chem 182: (2019) 108
- J Med Chem 58: 7431-48 (2015) 106
- Bioorg Med Chem Lett 26: 5044-5050 (2016) 106
- J Med Chem 55: 4286-96 (2012) 99
- J Med Chem 61: 6110-6120 (2018) 96
- J Med Chem 60: 362-372 (2017) 90
- J Med Chem 61: 10415-10439 (2018) 90
- US Patent US11905274 (2024) 90
- J Med Chem 64: 8246-8262 (2021) 88
- J Med Chem 65: 562-578 (2022) 87
- Eur J Med Chem 195: (2020) 86
- Bioorg Med Chem 20: 4217-25 (2012) 86
- J Med Chem 63: 9464-9483 (2020) 85
- Bioorg Med Chem Lett 22: 2456-9 (2012) 83
- US Patent US9273014 (2016) 82
- ACS Med Chem Lett 9: 422-427 (2018) 81
- ACS Med Chem Lett 7: 397-402 (2016) 80
- J Med Chem 59: 3264-71 (2016) 79
- Bioorg Med Chem 22: 6735-45 (2015) 76
- Eur J Med Chem 192: (2020) 76
- Bioorg Med Chem 22: 692-702 (2014) 76
- Chem Biol 22: 273-84 (2015) 74
- J Med Chem 63: 12942-12956 (2020) 70
- J Med Chem 53: 6112-21 (2010) 67
- Bioorg Med Chem 21: 11-20 (2012) 66
- J Med Chem 60: 9990-10012 (2017) 65
- Eur J Med Chem 197: (2020) 65
- Bioorg Med Chem Lett 20: 881-6 (2010) 64
- Bioorg Med Chem 23: 891-901 (2015) 64
- J Med Chem 58: 3957-74 (2015) 63
- Bioorg Med Chem Lett 26: 4552-4557 (2016) 62
- ...
Institutions 28▿
- Beijing Tide Pharmaceutical 886
- Vitae Pharmaceuticals 629
- The Regents of The University of Michigan 388
- Glaxosmithkline 364
- TBA 329
- University Of Michigan 326
- Chinese Academy Of Sciences 322
- Ucl Business 255
- University College London 242
- Bristol-Myers Squibb 224
- Exelixis 223
- Nanyang Normal University 214
- Sichuan University 190
- Shanghai Jiao Tong University 163
- Shenyang Pharmaceutical University 121
- University Of Chinese Academy Of Sciences 108
- Karo Pharma 90
- Beijing Tide Pharmaceutical Co. 90
- Dalian Institute of Chemical Physics 90
- Heinrich Heine University Duesseldorf 88
- Shanghai Institute Of Materia Medica 86
- Duquesne University 86
- Peking Union Medical College And Chinese Academy Of Medical Sciences 80
- University of Florida College of Medicine 74
- National Institute On Drug Abuse-Intramural Research Program 67
- Dalian University Of Technology 66
- Guizhou Medical University 65
- China Pharmaceutical University 64
- ...
Affinity: 0.0020 to 9.8E+7 nM▿
- Ki 1160
- IC50 8369
- Kd 273
- EC50 944
- Affinity ≤ nM
Xtal structures: 238
Docked structures: 12
Catalog Cmpds: 601